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McGovern, RE,Feifel, SC,Lisdat, F,Crowley, PB
Angewandte Chemie-International Edition
Microscale Crystals of Cytochromec and Calixarene on Electrodes: Interprotein Electron Transfer between Defined Sites
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calixarenes crystal growth heme proteins molecular glue redox chemistry BILIRUBIN OXIDASE C MULTILAYERS COMPLEX DEHYDROGENASE PROTEINS DYNAMICS GOLD
The assembly of redox proteins on electrodes is an important step in biosensor development. Recently, p-sulfonato-calix[4]arene was shown to act as molecular glue for the assembly and crystallization of cytochromec (cytc). Electrochemical data are presented for microscale cytc-calixarene crystals grown on self-assembled monolayers (SAM)-modified Au electrodes. The crystals were characterized by cyclic voltammetry and exceptionally high concentrations of electroactive cytc were obtained. The peak currents were found to increase linearly with the square root of the scan rate, thus allowing an evaluation of the rate constant for electron self-exchange. This study revealed high electroactivity accompanied by fast interprotein electron transfer in crystals, which may have implications for the construction of novel bioelectronic devices.
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