Peer-Reviewed Journal Details
Mandatory Fields
Lomas, AJ,Ryan, CNM,Sorushanova, A,Shologu, N,Sideri, AI,Tsioli, V,Fthenakis, GC,Tzora, A,Skoufos, I,Quinlan, LR,O'Laighin, G,Mullen, AM,Kelly, JL,Kearns, S,Biggs, M,Pandit, A,Zeugolis, DI
2015
April
Advanced Drug Delivery Reviews
The past, present and future in scaffold-based tendon treatments
Published
Optional Fields
Human and equine tendon injury Tendon cellular and extracellular composition Tendon healing Tissue grafts Biomaterials Sustained and localised delivery of therapeutics/biologics ANTERIOR CRUCIATE-LIGAMENT PLATELET-RICH PLASMA MESENCHYMAL STEM-CELLS DIGITAL FLEXOR TENDON TISSUE ENGINEERING APPLICATIONS HUMAN ACHILLES-TENDON MARROW STROMAL CELLS ROTATOR CUFF REPAIR GROWTH-FACTOR SUPPLEMENTATION PROXIMAL SUSPENSORY DESMITIS
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Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come. (C) 2014 Elsevier B.V. All rights reserved.
10.1016/j.addr.2014.11.022
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