Peer-Reviewed Journal Details
Mandatory Fields
Downey, RF,Sullivan, FJ,Wang-Johanning, F,Ambs, S,Giles, FJ,Glynn, SA
2015
September
International Journal Of Cancer
Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?
Published
Optional Fields
human endogenous retrovirus HERV-K carcinogenesis melanoma breast cancer prostate cancer HERV-K activation oncogenesis immunomodulation Env Gag Np9 Rec HUMAN-BREAST-CANCER MELANOMA-CELL LINES ZINC-FINGER PROTEIN HERV-K ENVELOPE PROTEIN INSERTIONAL POLYMORPHISMS PROSTATE-CANCER NITRIC-OXIDE ADOPTIVE IMMUNOTHERAPY MOLECULAR-MECHANISMS
137
1249
1257
Harbored as relics of ancient germline infections, human endogenous retroviruses (HERVs) now constitute up to 8% of our genome. A proportion of this sequence has been co-opted for molecular and cellular processes, beneficial to human physiology, such as the fusogenic activity of the envelope protein, a vital component of placentogenesis. However, the discovery of high levels of HERV-K mRNA and protein and even virions in a wide array of cancers has revealed that HERV-K may be playing a more sinister rolea role as an etiological agent in cancer itself. Whether the presence of this retroviral material is simply an epiphenomenon, or an actual causative factor, is a hotly debated topic. This review will summarize the current state of knowledge regarding HERV-K and cancer and attempt to outline the potential mechanisms by which HERV-K could be involved in the onset and promotion of carcinogenesis.
10.1002/ijc.29003
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