Peer-Reviewed Journal Details
Mandatory Fields
Shirazi, R.N., Aldabbagh, F., Erxleben, A., Rochev, Y., McHugh, P.E.
Acta Biomaterialia
Nanomechanical properties of poly (lactic-co-glycolic) acid film during degradation.
Optional Fields
Degradation Poly(lactic-co-glycolic) acid Solvent-cast film Nanoindentation
Despite the potential applications of poly(lactic-co-glycolic) acid (PLGA) coatings in medical devices, themechanical properties of this material during degradation are poorly understood. In the present work, the nanomechanical properties and degradation of PLGA film were investigated. Hydrolysis of solvent-cast PLGA film was studied in buffer solution at 37 C. The mass loss, water uptake, molecular weight, crystallinity and surface morphology of the film were tracked during degradation over 20 days. Characterization of the surface hardness and Young’s modulus was performed using the nanoindentation technique for different indentation loads. The initially amorphous films were found to remain amorphous during degradation. The molecular weight of the film decreased quickly during the initial days of degradation. Diffusion of water into the film resulted in a reduction in surface hardness during the first few days, followed by an increase that was due to the surface roughness. There was a significant delay between the decrease in the mechanical properties of the film and the decrease in the molecular weight. A sudden decline in mechanical properties indicated that significant bulk degradation had occurred.
Grant Details
Funding support was provided by the Structured PhD Programme in Biomedical Engineering and Regenerative Medicine (BMERM). Funded under the Programme for Research in Third- Level Institutions (PRTLI) Cycle 5 and co-funded under the European Regional Development Fund (ERDF).
Publication Themes