Computer simulation is used extensively in the design of permanent stents. In order to address newchallenges that arise in the design of absorbable metal stents (AMSs), such as corrosion and the limited mechanical properties of bioabsorbable alloys, new simulation and design techniques are needed. In this study a new method for simulating AMS corrosion is developed to study the effects of corrosion on the mechanical performance of a range of stent designs. The corrosion model is combined with an opti- mization strategy to identify AMS features that give optimal corrosion performance in the body. It is found that strut width is the predominant geometrical factor in determining long-term AMS scaffolding performance. An AMS with superior scaffolding performance to a commercial design is identiﬁed, based on deployment and corrosion simulations in stenosed vessels. These simulation and design techniques give new insights into in-vivo AMS performance and the role of device geometry in determining long-term scaffolding performance.