Peer-Reviewed Journal Details
Mandatory Fields
Tabrizi, L,Chiniforoshan, H,McArdle, P,Ebrahimi, M,Khayamian, T
2015
June
Inorganica Chimica Acta
A novel bioactive Cd(II) polymeric complex with mefenamic acid: Synthesis, crystal structure and biological evaluations
Published
WOS: 7 ()
Optional Fields
Cadmium(II) Mefenamic acid CT-DNA Cytotoxicity Antioxidant activity NONSTEROIDAL ANTIINFLAMMATORY DRUGS TOLFENAMIC ACID METAL-COMPLEXES SPECTROSCOPIC PROPERTIES DICLOFENAC COMPLEXES COBALT(II) COMPLEXES ANTIOXIDANT ACTIVITY CIRCULAR-DICHROISM INDUCED APOPTOSIS CATECHOL OXIDASE
432
176
184
A novel complex [Cd(mef)(2)(CH3OH)](n), 1, has been synthesized by the interaction of Cd(II) with the non-steroidal antiinflammatory drug mefenamic acid, mef, which has been structurally characterized by spectral (IR, UV-Vis) and X-ray crystallography. This complex is a 1D polymer, consisting of hepta-coordinated Cd atoms connected by six oxygen atoms from four different mef ligands and one oxygen atom from a methanol molecule. The coordination geometry around each metal ion is distorted by the bulky mef ligand. Binding of the synthesized complex with calf thymus DNA (CT-DNA) was investigated by spectroscopic methods (UV-Vis, fluorescence, CD spectroscopy) and viscosity measurements. The complex partially intercalated to DNA with high affinity. The antioxidant activities of ligand mef and complex 1 show this complex has better antioxidant activity than the free ligand. The antimicrobial activities of complex 1 are higher against both bacteria and fungi than free Cd2+ or mef. The cytotoxic effect of compound 1 on the human breast cancer cell line (MCF-7) and the bladder cancer cell line (T24) was also much higher than free Cd2+ or mef. (C) 2015 Elsevier B.V. All rights reserved.
10.1016/j.ica.2015.04.010
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