Peer-Reviewed Journal Details
Mandatory Fields
Zhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV
2015
April
Organic Letters
Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor
Published
()
Optional Fields
DIVERSITY-ORIENTED SYNTHESIS TERMINAL ALKYNES SCAFFOLDS CHEMISTRY METATHESIS PRECURSORS STRATEGY LECTINS PROTEIN AZIDES
17
1672
1675
A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.
10.1021/acs.orglett.5b00404
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