Peer-Reviewed Journal Details
Mandatory Fields
Tabrizi, L,Chiniforoshan, H,McArdle, P
2015
March
Spectrochimica Acta Part A-Molecular And Biomolecular Spectroscopy
A novel one-dimensional manganese(II) coordination polymer containing both dicyanamide and pyrazinamide ligands: Synthesis, spectroscopic investigations, X-ray studies and evaluation of biological activities
Published
WOS: 4 ()
Optional Fields
Manganese(II) Dicyanamide Pyrazinamide Antitumor activity Antibacterial activity MYCOBACTERIUM-TUBERCULOSIS CRYSTAL-STRUCTURES STRUCTURAL-CHARACTERIZATION METAL-COMPLEXES IR-SPECTRA FT-IR NETWORKS COPPER TETRACYANONICKELATE CHEMISTRY
139
307
312
A novel 1D coordination polymer {[Mn(mu(1,5)-dca)(2)(PZA)(2)](PZA)(2)}(n), 1, has been synthesized and characterized by single crystal X-ray crystallography. The coordination mode of dicyanamide (dca) and pyrazinamide (PZA) ligands was inferred by IR spectroscopy. The compound 1 was evaluated for in vitro antimycobacterial and antitumor activities. It demonstrated better in vitro activity against Mycobacterium tuberculosis than pyrazinamide and its MIC value was determined. Complex 1 was also screened for its in vitro antitumor activity towards LM3 and LP07 murine cancer cell lines. In addition, the antibacterial activity of complex 1 has been tested against Gram(+) and Gram(-) bacteria and it has shown promising broad range anti-bacterial activity. (C) 2014 Elsevier B.V. All rights reserved.
10.1016/j.saa.2014.12.072
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