Peer-Reviewed Journal Details
Mandatory Fields
Ronan, W,McMeeking, RM,Chen, CS,McGarry, JP,Deshpande, VS
Journal Of Biomechanics
Cooperative contractility: The role of stress fibres in the regulation of cell-cell junctions
WOS: 7 ()
Optional Fields
Mechanotransduction Stress fibre Junction force Myosin contractility Cell-cell junctions MECHANICAL MODEL CYTOSKELETON SUBSTRATE ELASTICITY SIMULATION TENSEGRITY STIFFNESS FORCE
We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces exerted by the cell and these show that the cell-cell tugging stress is a constant and independent of the cell-cell junction area. In the current study, we demonstrate that a material model which includes the underlying cellular processes of stress fibre contractility and adhesion formation can capture these results. The simulations explain the experimentally observed phenomena whereby the cell-cell junction forces increase with junction size but the tractions exerted by the cell on the micro-post array are independent of the junction size. Further simulations on different types of micro-post arrays and cell phenotypes are presented as a guide to future experiments. (C) 2014 Elsevier Ltd. All rights reserved.
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