Peer-Reviewed Journal Details
Mandatory Fields
Connolly, PF,Jager, R,Fearnhead, HO
2014
April
Frontiers in physiology
New roles for old enzymes: killer caspases as the engine of cell behavior changes
Published
Optional Fields
caspase apoptosis myogenesis proliferation differentiation non-apoptotic roles SKELETAL-MUSCLE REGENERATION NON-APOPTOTIC ROLE TERMINAL DIFFERENTIATION IMMUNE-RESPONSES ACTIVE CASPASE-3 BERGMANN GLIA CYTOCHROME-C ACTIVATION DEATH IDENTIFICATION
5
It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal remodeling, and caspases are now known to have an essential role in cell proliferation, migration, and differentiation. There is also evidence that apoptotic cells themselves can direct the behavior of nearby cells through the caspase-dependent secretion of paracrine signaling factors. In some processes, including the differentiation of skeletal muscle myoblasts, both caspase activation in differentiating cells as well as signaling from apoptotic cells has been reported. Here, we review the non-apoptotic outcomes of caspase activity in a range of different model systems and attempt to integrate this knowledge.
10.3389/fphys.2014.00149
Grant Details
Publication Themes