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Maung, SW,Leahy, M,O'Leary, HM,Khan, I,Cahill, MR,Gilligan, O,Murphy, P,McPherson, S,Jackson, F,Ryan, M,Hennessy, B,McHugh, J,Goodyer, M,Bacon, L,O'Gorman, P,Nee, A,O'Dwyer, M,Enright, H,Saunders, J,O'Keeffe, D
2013
October
British Journal Of Haematology
A multi-centre retrospective study of rituximab use in the treatment of relapsed or resistant warm autoimmune haemolytic anaemia
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multicentre safety rituximab autoimmune haemolytic anaemia retrospective ADULT PATIENTS THERAPY EFFICACY SPLENECTOMY SAFETY
163
118
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This retrospective analysis assessed the response, safety and duration of response to standard dose rituximab 375 mg/m(2) weekly for four weeks as therapy for patients with primary or secondary warm autoimmune haemolytic anaemia (WAIHA), who had failed initial treatment. Thirty-four patients received rituximab for WAIHA in seven centres in the Republic of Ireland. The overall response rate was 70 center dot 6% (24/34) with 26 center dot 5% (9/34) achieving a complete response (CR). The time to response was 1 month post-initiation of rituximab in 87 center dot 5% (21/24) and 3 months in 12 center dot 5% (3/24) of patients. The median duration of follow-up was 36 months (range 6-90 months). Of the patients who responded, 50% (12/24) relapsed during follow up with a median time to next treatment of 16 center dot 5 months (range 6-60 months). Three patients were re-treated with rituximab 375 mg/m2 weekly for four weeks at relapse and responded. There was a single episode of neutropenic sepsis. Rituximab is an effective and safe treatment for WAIHA but a significant number of patients will relapse in the first two years post treatment. Re-treatment was effective in a small number of patients, suggesting that intermittent pulse treatment or maintenance treatment may improve long-term response.
10.1111/bjh.12486
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