Peer-Reviewed Journal Details
Mandatory Fields
Smyth, A,O'Donnell, MJ,Yusuf, S,Clase, CM,Teo, KK,Canavan, M,Reddan, DN,Mann, JFE
2014
October
American Journal Of Hypertension
Sodium Intake and Renal Outcomes: A Systematic Review
Published
Optional Fields
blood pressure chronic kidney disease clinical epidemiology hypertension nutrition CHRONIC KIDNEY-DISEASE COMPENSATED HEART-FAILURE IMPROVING GLOBAL OUTCOMES BLOOD-PRESSURE CARDIOVASCULAR-DISEASE SALT INTAKE NONPHARMACOLOGIC INTERVENTIONS RISK HYPERTENSION PROGRESSION
27
1277
1284
BACKGROUNDSodium intake is an important determinant of blood pressure; therefore, reduction of intake may be an attractive population-based target for chronic kidney disease (CKD) prevention. Most guidelines recommend sodium intake of 4.6 g/day) was associated with adverse outcomes (vs. moderate/low), while none reported an increased risk with moderate intake (vs. low). Three studies (n = 6,342) included patients without CKD. Two cohort studies (n = 6,155) reported opposing directions of association between low (vs. moderate) sodium intake and renal outcomes, and one clinical trial (n = 187) reported a benefit from low intake (vs. moderate) on proteinuria but an adverse effect on serum creatinine.CONCLUSIONSAvailable, but limited, evidence supports an association between high sodium intake (>4.6 g/day) and adverse outcomes. However, the association with low intake (vs. moderate) is uncertain, with inconsistent findings from cohort studies. There is urgent need to clarify the long-term efficacy and safety of currently recommended low sodium intake in patients with CKD.
10.1093/ajh/hpt294
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