Peer-Reviewed Journal Details
Mandatory Fields
Ferreira, M. A.,O'Donovan, M. C.,Meng, Y. A.,Jones, I. R.,Ruderfer, D. M.,Jones, L.,Fan, J.,Kirov, G.,Perlis, R. H.,Green, E. K.,Smoller, J. W.,Grozeva, D.,Stone, J.,Nikolov, I.,Chambert, K.,Hamshere, M. L.,Nimgaonkar, V. L.,Moskvina, V.,Thase, M. E.,Caesar, S.,Sachs, G. S.,Franklin, J.,Gordon-Smith, K.,Ardlie, K. G.,Gabriel, S. B.,Fraser, C.,Blumenstiel, B.,Defelice, M.,Breen, G.,Gill, M.,Morris, D. W.,Elkin, A.,Muir, W. J.,McGhee, K. A.,Williamson, R.,MacIntyre, D. J.,MacLean, A. W.,St, C. D.,Robinson, M.,Van Beck, M.,Pereira, A. C.,Kandaswamy, R.,McQuillin, A.,Collier, D. A.,Bass, N. J.,Young, A. H.,Lawrence, J.,Ferrier, I. N.,Anjorin, A.,Farmer, A.,Curtis, D.,Scolnick, E. M.,McGuffin, P.,Daly, M. J.,Corvin, A. P.,Holmans, P. A.,Blackwood, D. H.,Gurling, H. M.,Owen, M. J.,Purcell, S. M.
2008
September
Nature Genetics
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
Published
()
Optional Fields
40
99
1056
8
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
1061-4036 (Print)1061-40
http://www.ncbi.nlm.nih.gov/pubmed/18711365
Grant Details
Publication Themes