Peer-Reviewed Journal Details
Mandatory Fields
Donohoe, G.,Frodl, T.,Morris, D.,Spoletini, I.,Cannon, D. M.,Cherubini, A.,Caltagirone, C.,Bossu, P.,McDonald, C.,Gill, M.,Corvin, A. P.,Spalletta, G.
2010
January
Neuropsychopharmacology
Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia
Published
()
Optional Fields
35
22
368
73
A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry, whole-volume analysis revealed significantly reduced GMVs in both the right dorsolateral prefrontal and left occipital cortex, corresponding to the behavioral findings of impaired spatial working memory and EEG findings of impaired visual processing already reported. These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased.A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry, whole-volume analysis revealed significantly reduced GMVs in both the right dorsolateral prefrontal and left occipital cortex, corresponding to the behavioral findings of impaired spatial working memory and EEG findings of impaired visual processing already reported. These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased.
1740-634X (Electronic)00
http://www.ncbi.nlm.nih.gov/pubmed/19794403
Grant Details
Publication Themes