Acculturation occurs when people of different cultural backgrounds come into continuous, firsthand contact, as occurs following migration. Adolescents and young adults make up a large proportion of international migrants, yet there is little qualitative research available on their experiences when engaging with the process of acculturative change. This meta-ethnography synthesizes published qualitative studies of adolescent acculturation to draw together findings on this important developmental issue. A literature search was conducted to identify qualitative studies that have investigated acculturation among adolescent migrant youth. Eleven different studies were identified, most of which involved immigrants to the U.S. These were reviewed using the meta-ethnographic research process. We identified four themes to represent how adolescents engaged with the process of acculturation, integrated using a line-of-argument. While broadly consistent with existing acculturation frameworks, our findings highlight domain-specificity, structural and socio-historical challenges, personal meaning-making, and opportunities for personal growth as emergent features in the qualitative literature. The line-of-argument is used to critique and extend the dominant conceptual frameworks on acculturation from a contextual perspective. (C) 2013 Elsevier Ltd. All rights reserved.