Peer-Reviewed Journal Details
Mandatory Fields
Dong, YX,Hassan, WU,Kennedy, R,Greiser, U,Pandit, A,Garcia, Y,Wang, WX
2014
May
Acta Biomaterialia
Performance of an in situ formed bioactive hydrogel dressing from a PEG-based hyperbranched multifunctional copolymer
Published
WOS: 49 ()
Optional Fields
In situ cross-link PEG based hyperbranched polymer Hydrogel dressing Adipose derived stem cells Wound healing MESENCHYMAL STEM-CELLS WOUND REPAIR STROMAL CELLS ADIPOSE-TISSUE BONE-MARROW GROWTH-FACTORS SKIN DIFFERENTIATION DELIVERY ANGIOGENESIS
10
2076
2085
Hydrogel dressings have been widely used for wound management due to their ability to maintain a hydrated wound environment, restore the skin's physical barrier and facilitate regular dressing replacement. However, the therapeutic functions of standard hydrogel dressings are restricted. In this study, an injectable hybrid hydrogel dressing system was prepared from a polyethylene glycol (PEG)-based thermoresponsive hyperbranched multiacrylate functional copolymer and thiol-modified hyaluronic acid in combination with adipose-derived stem cells (ADSCs). The cell viability, proliferation and metabolic activity of the encapsulated ADSCs were studied in vitro, and a rat dorsal full-thickness wound model was used to evaluate this bioactive hydrogel dressing in vivo. It was found that long-term cell viability could be achieved for both in vitro (21 days) and in vivo (14 days) studies. With ADSCs, this hydrogel system prevented wound contraction and enhanced angiogenesis, showing the potential of this system as a bioactive hydrogel dressing for wound healing. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
10.1016/j.actbio.2013.12.045
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