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McDermott, AM,Chang, KH,Mieske, K,Abeidi, A,Harte, BH,Kerin, MJ,McAnena, OJ
2014
February
Journal Of Clinical Anesthesia
Total systemic ropivacaine concentrations following aerosolized intraperitoneal delivery using the AeroSurge
Published
Altmetric: 4WOS: 6 ()
Optional Fields
Anesthetics, local Cholecystectomy, laparoscopic Drug administration routes Lapatoscopy LAPAROSCOPIC CHOLECYSTECTOMY EPIDURAL-ANESTHESIA POSTOPERATIVE PAIN BUPIVACAINE PHARMACOKINETICS INSTILLATION MANAGEMENT ANALGESIA RESPONSES SURGERY
26
18
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Study Objective: To evaluate intraperitoneal ropivacaine delivery with the AeroSurge device in the clinical setting and to evaluate the total systemic ropivacaine levels achieved following delivery of 50 mg of aerosolized ropivacaine.Design: Preliminary, prospective, nonrandomized study.Setting: Operating room of a university hospital.Patients: 5 consecutive ASA physical status 1 and 2 patients undergoing elective laparoscopic Nissen fundoplication or cholecystectomy.Intervention: Five mL of 1% ropivacaine was delivered through the 10 mm port using the AeroSurge device at peritoneal insufflation.Measurements: Venous blood samples were collected and total ropivacaine concentration was determined using liquid chromatography-mass spectrometry.Main Results: The AeroSurge device delivered ropivacaine, visible as mist within the peritoneal cavity. Peak concentration (C-max) was attained between 10 and 30 minutes following the end of aerosolized ropivacaine delivery. At no stage did any level approach toxic levels.Conclusions: This preliminary study confirms that, aerosolized intraperitoneal local anesthetic is feasible, with ropivacaine concentrations remaining within safe levels. (C) 2014 Elsevier Inc. All rights reserved.
10.1016/j.jclinane.2013.07.013
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