Peer-Reviewed Journal Details
Mandatory Fields
Abbah, SA,Spanoudes, K,O'Brien, T,Pandit, A,Zeugolis, DI
2014
March
Stem Cell Research & Therapy
Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models
Published
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Optional Fields
PLATELET-RICH PLASMA MARROW STROMAL CELLS CRUCIATE LIGAMENT RECONSTRUCTION RABBIT ACHILLES-TENDON DIGITAL FLEXOR TENDON LIQUID FIBRIN MATRIX BONE-MARROW EXTENSOR TENDONS ROTATOR CUFF THERAPEUTIC-EFFICACY
5
Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional recovery, imposing the need for the development of therapeutic strategies. The limited number of low activity/reparative capacity tendon-resident cells has directed substantial research efforts towards the exploration of the therapeutic potential of various stem cells in tendon injuries and pathophysiologies. Severe injuries require the use of a stem cell carrier to enable cell localisation at the defect site. The present study describes advancements that injectable carriers, tissue grafts, anisotropically orientated biomaterials, and cell-sheets have achieved in preclinical models as stem cell carriers for tendon repair.
10.1186/scrt426
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