Peer-Reviewed Journal Details
Mandatory Fields
Subhash, HM,Leahy, MJ
2014
February
Journal Of Biomedical Optics
Microcirculation imaging based on full-range high-speed spectral domain correlation mapping optical coherence tomography
Published
WOS: 21 ()
Optional Fields
optical coherence tomography spectral interferometry microcirculation imaging image processing optical imaging correlation mapping RETINAL BLOOD-FLOW IN-VIVO SWEPT-SOURCE DOPPLER TOMOGRAPHY ANGIOGRAPHY MICROVASCULATURE OCT MICROANGIOGRAPHY PERFUSION CONTRAST
19
Microcirculation imaging is a key parameter for studying the pathophysiological processes of various disease conditions, in both clinical and fundamental research. A full-range spectral-domain correlation mapping optical coherence tomography (cm-OCT) method to obtain a complex-conjugate-free, full-range depth-resolved microcirculation map is presented. The proposed system is based on a high-speed spectrometer at 91 kHz with a modified scanning protocol to achieve higher acquisition speed to render cm-OCT images with highspeed and wide scan range. The mirror image elimination is based on linear phase modulation of B-frames by introducing a slight off-set of the probe beam with respect to the lateral scanning fast mirror's pivot axis. An algorithm that exploits the Hilbert transform to obtain a complex-conjugate-free image in conjunction with the cm-OCT algorithm is used to obtain full-range imaging of microcirculation within tissue beds in vivo. The estimated sensitivity of the system was around 105 dB near the zero-delay line with similar to 20 dB roll-off from +/-0.5 to +/-3 mm imaging-depth position. The estimated axial and lateral resolutions are similar to 12 and similar to 30 mu m, respectively. A direct consequence of this complex conjugate artifact elimination is the enhanced flow imaging sensitivity for deep tissue imaging application by imaging through the most sensitive zero-delay line and doubling the imaging range. (C) The Authors.
10.1117/1.JBO.19.2.021103
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