Peer-Reviewed Journal Details
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Amer, H,Griffin, MD
2014
February
Kidney International
Modulating kidney transplant interstitial fibrosis and tubular atrophy: is the RAAS an important target?
Published
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RENAL-TRANSPLANTATION GRAFT-SURVIVAL RENIN ALDOSTERONE RECIPIENTS HISTOLOGY BLOCKADE
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In follow-up to a recently published randomized controlled clinical trial, lssa et al. provide evidence that systemic activity and physiological responsiveness of the renin aldosterone angiotensin system (RAAS) are well within normal limits in most kidney recipients during the first 5 years post-transplant. Implications of the results include the need to better understand intra-renal RAAS activity in transplanted kidneys and to identify patients in which the graft-protective effects of RAAS blockade are most relevant.
DOI 10.1038/ki.2013.400
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