Peer-Reviewed Journal Details
Mandatory Fields
Lowndes NF, Murguia JR
2000
February
Gene
Sensing and responding to DNA damage.
Published
()
Optional Fields
10
1
17
25
DNA damage or stalled DNA replication can activate specific signal transduction pathways, termed checkpoints. Checkpoint activation can result in increased repair, induction of a transcriptional programme and inhibition of cell-cycle progression. Recent results have suggested possible mechanisms for the detection of specific DNA structures, provided further information on the organisation of the signal transduction cascade and demonstrated involvement of the checkpoint pathway in DNA repair.
Grant Details
Publication Themes