Peer-Reviewed Journal Details
Mandatory Fields
Toh GW, Lowndes NF
2003
February
Biochemical Society Transactions
Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage.
Published
Optional Fields
31
Pt 1
242
246
Eukaryotic cells have evolved surveillance mechanisms, known as DNA-damage checkpoints, that sense and respond to genome damage. DNA-damage checkpoint pathways ensure co-ordinated cellular responses to DNA damage, including cell cycle delays and activation of repair mechanisms. RAD9, from Saccharomyces cerevisiae, was the first damage checkpoint gene to be identified, although its biochemical function remained unknown until recently. This review examines briefly work that provides significant insight into how Rad9 activates the checkpoint signalling kinase Rad53.
10.1042/
Grant Details
Publication Themes