Peer-Reviewed Journal Details
Mandatory Fields
Costelloe T, Fitzgerald J, Murphy NJ, Flaus A, Lowndes NF
2006
August
Experimental Cell Research
Chromatin modulation and the DNA damage response.
Published
()
Optional Fields
312
14
2677
2686
The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.
10.1016/j.yexcr.2006.06.031
Grant Details
Publication Themes