Other Publication Details
Mandatory Fields
Reviews
Aied, A,Greiser, U,Pandit, A,Wang, WX
2013
November
Polymer gene delivery: overcoming the obstacles
Published
1
Optional Fields
NUCLEAR-LOCALIZATION SIGNALS IN-VIVO DISTRIBUTION TRANSFECTION EFFICIENCY BLOCK-COPOLYMER NONVIRAL VECTOR DNA DELIVERY CELL-LINE POLYETHYLENIMINE POLYPLEXES COMPLEXES
Recent progress in gene therapy has opened doors for the development of new and multifunctional delivery agents based on the tailored synthesis of polymers. These polymers are in their infancy compared with viral agents, which have been optimised during millions of years of evolution, making viral vectors naturally efficient transfection agents. To improve the efficiency of polymer gene delivery to the level seen in viral vectors, it is necessary to understand the challenges faced by polymer gene delivery vectors both in vitro and in vivo. In this review, we analyse and discuss those obstacles that scientists have to overcome to design a highly efficient synthetic transfection agent.
1090
1098
DOI 10.1016/j.drudis.2013.06.014
Grant Details
Publication Themes