Peer-Reviewed Journal Details
Mandatory Fields
Howley B, Fearnhead HO
2008
September
Journal Of Cellular And Molecular Medicine
Caspases as therapeutic targets.
Published
()
Optional Fields
12
5A
1502
1516
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase-associated disorders while focusing on caspase-1 inhibition as a potential therapeutic strategy. Problems facing the development of effective and safe caspase therapeutics will also be addressed.
10.1111/j.1582-4934.2008.00292.x
Grant Details
Publication Themes