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Howard Fearnhead
Mechanisms of Cell Death - The command to die
International Cell Death Society Meeting
Invited Lecture
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Anisomycin analogues induce cell death in multi-drug-resistant cancer cells in the absence of JNK activation and protein synthesis inhibition AUTHORS: David Monaghan1, Enda O’Connell2, Faye L. Cruikshank3, Francis J. Giles4,5, Francis J. Sullivan4,5, Alison N. Hulme3, Howard O. Fearnhead1 AFFILIATIONS: 1Pharmacology and Therapeutics, 2Screening Laboratory, National Centre for Biomedical Engineering Research, National University of Ireland Galway, Galway, Ireland, 3School of Chemistry, University of Edinburgh, UK, 4Prostate Cancer Institute, National University of Ireland, Galway, 5HRB Clinical Research Facility, Galway. Anisomycin was identified in a screen of clinical compounds as a drug that kills a multi-drug resistant breast cancer cell line as well as other triple-negative breast and prostate cancer lines. We show for the first time that anisomycin analogues that do not inhibit protein synthesis or activate JNK retain the ability to induce cell death. Our findings significantly strengthen the case for re-purposing anisomycin and the development of anisomycin analogues for the treatment of drug-resistant cancers.
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