Peer-Reviewed Journal Details
Mandatory Fields
Dwyer RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Hennessy E, Murphy JM, Barry FP, O'Brien T, Kerin MJ
2007
September
Cancer Research
Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells.
Published
Altmetric: 1WOS: 278 ()
Optional Fields
13
17
5020
5027
Major barriers to effective adenovirus-based gene therapy include induction of an immune response and tumor-specific targeting of vectors. The use of mesenchymal stem cells (MSC) as systemic delivery vehicles for therapeutic genes has been proposed as a result of their combined ability to home in on the tumor site and evade the host immune response. This study is aimed at investigating factors mediating homing of human MSCs to breast cancer primary cultures and cell lines in vitro and in vivo.
10.1158/1078-0432.CCR-07-0731
Grant Details
Publication Themes