Peer-Reviewed Journal Details
Mandatory Fields
McGinley L, McMahon J, Strappe P, Barry F, Murphy M, O'Toole D, O'Brien T
2011
March
Stem Cell Research & Therapy
Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia.
Published
Altmetric: 1WOS: 56 ()
Optional Fields
2
2
A combination of gene and cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal stem cells (MSCs). The development of efficient gene delivery methods is essential if MSCs are to be of benefit using such an approach. Achieving high levels of transgene expression for the required period of time, without adversely affecting cell viability and differentiation capacity, is crucial. In the present study, we investigate lentiviral vector-mediated genetic modification of rat bone-marrow derived MSCs and examine any functional effect of such genetic modification in an in vitro model of ischaemia.
10.1186/scrt53
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