Peer-Reviewed Journal Details
Mandatory Fields
Cotter JJ, O'Gara JP, Mack D, Casey E
2009
January
Applied And Environmental Microbiology
Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis.
Published
()
Optional Fields
75
1
261
264
Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of sigma(B). Under anaerobic conditions, increased sigma(B) activity activates icaADBC, which encodes enzymes responsible for polysaccharide intercellular adhesin synthesis, by repressing transcription of the negative regulator icaR.
10.1128/AEM.00261-08
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