Peer-Reviewed Journal Details
Mandatory Fields
Glynn SA, Adams A, Gibson B, Cronin D, Harmey JH, Clynes M
2006
March
Anticancer Research
Low adhesiveness coupled with high superinvasiveness in vitro predicts the in vivo metastatic potential of a mouse mammary adenocarcinoma cell line.
Published
()
Optional Fields
26
2A
1001
1010
We have previously shown that the selection of cancer cell lines with chemotherapeutic agents can alter the invasive potential of the cells, resulting in a superinvasive phenotype, where cells not only invade through matrigel and migrate through membrane pores, but also subsequently detach from the underside of the invasion chamber, survive in suspension and ultimately attach to and grow on the bottom of the well beneath the insert. In order to determine the significance of this in vivo, the following experiments were performed.
Grant Details
Publication Themes