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Riegler, J,Liew, A,Hynes, SO,Ortega, D,O'Brien, T,Day, RM,Richards, T,Sharif, F,Pankhurst, QA,Lythgoe, MF
2013
March
Biomaterials
Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury
Published
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Magnetic targeting Stem cell Nanoparticle Restenosis Catheter ENDOTHELIAL PROGENITOR CELLS PERIPHERAL ARTERIAL-DISEASE MESENCHYMAL STEM-CELLS BONE-MARROW-CELLS NEOINTIMAL HYPERPLASIA MYOCARDIAL-INFARCTION TASK-FORCE DELIVERY ATHEROSCLEROSIS ANGIOPLASTY
34
1987
1994
Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. Cells labelled with superparamagnetic iron oxide nanoparticles exhibit no negative effects on cell viability, differentiation or secretion patterns. The increase in stem cell retention leads to a reduction in restenosis three weeks after cell delivery. (C) 2012 Elsevier Ltd. All rights reserved.
DOI 10.1016/j.biomaterials.2012.11.040
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