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Daly, SM,Leahy, MJ
2013
March
"Go with the flow ': A review of methods and advancements in blood flow imaging
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1
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biophotonics correlation flow microcirculation microvasculature optical imaging optical sectioning photoacoustic optical coherence tomography OPTICAL COHERENCE TOMOGRAPHY LASER-DOPPLER FLOWMETRY MICROVASCULAR PLASMA PERFUSION MAGNETIC-RESONANCE ANGIOGRAPHY THERMODILUTION CARDIAC-OUTPUT SCANNING CONFOCAL MICROSCOPY POSITRON-EMISSION-TOMOGRAPHY CIRCULATING TUMOR-CELLS BREAST-CANCER PATIENTS SPECKLE VARIANCE OCT
Physics has delivered extraordinary developments in almost every facet of modern life. From the humble thermometer and stethoscope to X-Ray, CT, MRI, ultrasound, PET and radiotherapy, our health has been transformed by these advances yielding both morphological and functional metrics. Recently high resolution label-free imaging of the microcirculation at clinically relevant depths has become available in the research domain. In this paper, we present a comprehensive review on current imaging techniques, state-of-the-art advancements and applications, and general perspectives on the prospects for these modalities in the clinical realm. ((c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
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DOI 10.1002/jbio.201200071
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