Peer-Reviewed Journal Details
Mandatory Fields
Alsharabasy, AM;Glynn, SA;Pandit, A
2020
December
Biochemical Society Transactions
The role of extracellular matrix in tumour angiogenesis: the throne has NOx servants
Published
Optional Fields
NITRIC-OXIDE SYNTHASE NEGATIVE BREAST-CANCER GROWTH-FACTOR SHEAR-STRESS MOLECULAR ASPECTS COLON-CANCER REGULATES MATRIX-METALLOPROTEINASE-9 MATRICELLULAR PROTEINS ENDOTHELIAL-CELLS COLORECTAL-CANCER
48
2539
2555
The extracellular matrix (ECM) dynamics in tumour tissue are deregulated compared to the ECM in healthy tissue along with disorganized architecture and irregular behaviour of the residing cells. Nitric oxide (NO) as a pleiotropic molecule exerts different effects on the components of the ECM driving or inhibiting augmented angiogenesis and tumour progression and tumour cell proliferation and metastasis. These effects rely on the concentration of NO within the tumour tissue, the nature of the surrounding microenvironment and the sensitivity of resident cells to NO. In this review article, we summarize the recent findings on the correlation between the levels of NO and the ECM components towards the modulation of tumour angiogenesis in different types of cancers. These are discussed principally in the context of how NO modulates the expression of ECM proteins resulting in either the promotion or inhibition of tumour growth via tumour angiogenesis. Furthermore, the regulatory effects of individual ECM components on the expression of the NO synthase enzymes and NO production were reviewed. These findings support the current efforts for developing effective therapeutics for cancers.
0300-5127
10.1042/BST20200208
Grant Details
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