Peer-Reviewed Journal Details
Mandatory Fields
Laffey JG, Engelberts D, Duggan M, Veldhuizen R, Lewis JF, Kavanagh BP
2003
November
Critical Care Medicine
Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation.
Published
()
Optional Fields
31
11
2634
2640
Deliberate elevation of PaCO2 (therapeutic hypercapnia) protects against lung injury induced by lung reperfusion and severe lung stretch. Conversely, hypocapnic alkalosis causes lung injury and worsens lung reperfusion injury. Alterations in lung surfactant may contribute to ventilator-associated lung injury. The potential for CO2 to contribute to the pathogenesis of ventilator-associated lung injury at clinically relevant tidal volumes is unknown. We hypothesized that: 1) hypocapnia would worsen ventilator-associated lung injury, 2) therapeutic hypercapnia would attenuate ventilator-associated lung injury; and 3) the mechanisms of impaired compliance would be via alteration of surfactant biochemistry.
10.1097/01.CCM.0000089646.52395.BA
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