Peer-Reviewed Journal Details
Mandatory Fields
Kavanagh BP, Laffey JG
2006
June
Minerva anestesiologica
Hypercapnia: permissive and therapeutic.
Published
()
Optional Fields
72
6
567
576
Hypercapnia has traditionally been avoided in the quest to keep parameters normal. Recent understanding of the role of excessive tidal stretch has prompted clinicians to avoid high tidal volumes or plateau pressures, and the resulting permissive hypercapnia has been increasingly tolerated by clinicians. Newer data point to the potential for elevated CO2 to be protective, and in some experimental situations, to cause harm. The protective effects of so called therapeutic hypercapnia' remain experimental at present, but promising laboratory studies suggest potential roles for the eventual selective application at the bedside.
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