Peer-Reviewed Journal Details
Mandatory Fields
Hassett P, Curley GF, Contreras M, Masterson C, Higgins BD, O'Brien T, Devaney J, O'Toole D, Laffey JG
2011
October
Intensive care medicine
Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury.
Published
()
Optional Fields
37
10
1680
1687
Superoxide is produced by activated neutrophils during the inflammatory response to stimuli such as endotoxin, can directly or indirectly injure host cells, and has been implicated in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). We wished to determine the potential for pulmonary overexpression of the extracellular isoform of superoxide dismutase (EC-SOD) to reduce the severity of endotoxin-induced lung injury.
10.1007/s00134-011-2309-y
Grant Details
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