Peer-Reviewed Journal Details
Mandatory Fields
Troisi, J.; Autio, R.; Beopoulos, T.; Bravaccio, C.; Carraturo, F.; Corrivetti, G.; Cunningham, S.; Devane, S.; Fallin, D.; Fetissov, S.; Gea, M.; Giorgi, A.; Iris, F.; Joshi, L.; Kadzielski, S.; Kraneveld, A.; Kumar, H.; Ladd-Acosta, C.; Leader, G.; Mannion, A.; Maximin, E.; Mezzelani, A.; Milanesi, L.; Naudon, L.; Marzal, L.N.P.; Pardo, P.P.; Prince, N.Z.; Rabot, S.; Roeselers, G.; Roos, C.; Roussin, L.; Scala, G.; Tuccinardi, F.P.; Fasano, A.
2020
October
Brain Sciences
Genome, Environment, Microbiome and Metabolome in Autism (GEMMA) Study Design: Biomarkers Identification for Precision Treatment and Primary Prevention of Autism Spectrum Disorders by an Integrated Multi-Omics Systems Biology Approach
Published
()
Optional Fields
microbiome; metabolomics; autism; study design; biomarker discovery; precise medicine
10
10
743
Autism Spectrum Disorder (ASD) affects approximately 1 child in 54, with a 35-fold increase since 1960. Selected studies suggest that part of the recent increase in prevalence is likely attributable to an improved awareness and recognition, and changes in clinical practice or service availability. However, this is not sufficient to explain this epidemiological phenomenon. Research points to a possible link between ASD and intestinal microbiota because many children with ASD display gastro-intestinal problems. Current large-scale datasets of ASD are limited in their ability to provide mechanistic insight into ASD because they are predominantly cross-sectional studies that do not allow evaluation of perspective associations between early life microbiota composition/function and later ASD diagnoses. Here we describe GEMMA (Genome, Environment, Microbiome and Metabolome in Autism), a prospective study supported by the European Commission, that follows at-risk infants from birth to identify potential biomarker predictors of ASD development followed by validation on large multi-omics datasets. The project includes clinical (observational and interventional trials) and pre-clinical studies in humanized murine models (fecal transfer from ASD probands) and in vitro colon models. This will support the progress of a microbiome-wide association study (of human participants) to identify prognostic microbiome signatures and metabolic pathways underlying mechanisms for ASD progression and severity and potential treatment response.
https://www.mdpi.com/2076-3425/10/10/743
:10.3390/brainsci10100743
Grant Details
EU
GEMMA project was funded by the European Commission by means of the Horizon 2020 program (call H2020-SC1-BHC-03-2018) with the project ID 825033.
Publication Themes