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Miller, N,McCann, AH,O'Connell, D,Pedersen, IS,Spiers, V,Gorey, T,Dervan, PA
1997
December
Genomics
The MAS proto-oncogene is imprinted in human breast tissue
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FACTOR-II GENE MESSENGER-RNA RAT-BRAIN IGF2 GENE EXPRESSION PROTOONCOGENE MOUSE ACTIVATION RELAXATION P57(KIP2)
46
509
512
The human MAS proto-oncogene is situated at 6q25.3-q26, a region that is homologous to mouse chromosome 17 where two parentally imprinted genes (Mas and Igf2r) have previously been identified. We investigated the imprinting status of MAS in adult lesions to establish the imprinting status of this gene in humans, as certain imprinted genes are known to have altered imprinting phenotypes in cancer. Of 14 breast samples demonstrating a MAS RT-PCR product, 4 were informative for a polymorphic marker. In all 4 cases, expression of the MAS gene was found to be mono-allelic, indicating the presence of a functional imprint at this locus in human breast tissue. (C) 1997 Academic Press.
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