Peer-Reviewed Journal Details
Mandatory Fields
O'Loughlin, A,McIntosh, C,Dinneen, SF,O'Brien, T
2010
June
International Journal Of Lower Extremity Wounds
Basic Concepts to Novel Therapies: A Review of the Diabetic Foot
Published
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Optional Fields
diabetes foot ulcer neuropathy ischemia amputation RANDOMIZED CONTROLLED-TRIAL QUALITY-OF-LIFE HYPERBARIC-OXYGEN THERAPY VACUUM-ASSISTED CLOSURE POPULATION-BASED COHORT PRESSURE WOUND THERAPY LOWER-EXTREMITY CLINICAL-TRIAL PERIPHERAL NEUROPATHY SCREENING TECHNIQUES
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90
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Diabetes mellitus is a global epidemic. Peripheral neuropathy and peripheral vascular disease are complications of diabetes mellitus and the primary causative factors for foot ulceration. Foot ulceration is the leading cause of hospitalization in people with diabetes mellitus. The burden of foot ulceration on health care systems and individual patients is immense. Despite conventional treatment, there persists a high incidence of amputation. A multidisciplinary approach is required to prevent ulcers. This review describes the etiology and risk factors for diabetic foot ulceration and a system for evaluating the diabetic foot. The assessment of neuropathy and the grading of foot ulcers are critically examined. This is important to allow for standardization in clinical trials. The management of diabetic foot syndrome is reviewed. The treatments to ensure vascular supply to the lower limb and control of infection as well as novel therapies, which are becoming available to treat nonhealing, "no-option" diabetic ulcers, are discussed.
DOI 10.1177/1534734610371600
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