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Mandatory Fields
Tronchin, G,Akudjedu, TN,Kenney, JP,McInerney, S,Scanlon, C,McFarland, J,McCarthy, P,Cannon, DM,Hallahan, B,McDonald, C
2020
August
Psychiatry Research-Neuroimaging
Cognitive and Clinical Predictors of Prefrontal Cortical Thickness Change Following First-Episode of Psychosis
Published
Optional Fields
First-episode psychosis Cognitive impairment Magnetic resonance imaging Cortical thickness Longitudinal study Negative symptoms MAGNETIC-RESONANCE SPECTROSCOPY 1ST EPISODE PSYCHOSIS SYNDROME SCALE PANSS EXECUTIVE FUNCTION SOCIAL COGNITION GEOMETRICALLY ACCURATE NEGATIVE SYMPTOMS ONSET PSYCHOSIS FRONTAL-CORTEX MATTER VOLUME
302
The association of neuroanatomical progression with cognitive and clinical deterioration after first-episode of psychosis remains uncertain. This longitudinal study aims to assess whether i)impaired executive functioning and emotional intelligence at first presentation are associated with progressive prefrontal and orbitofrontal cortical thinning ii)negative symptom severity is linked to progressive prefrontal cortical thinning. 1.5T MRI images were acquired at baseline and after 3.5 years for 20 individuals with first-episode psychosis and 18 controls. The longitudinal pipeline of Freesurfer was employed to parcellate prefrontal cortex at two time points. Baseline cognitive performance was compared between diagnostic groups using MANCOVA. Partial correlations investigated relationships between cognition and negative symptoms at baseline and cortical thickness change over time. Patients displayed poorer performance than controls at baseline in working memory, reasoning/ problem solving and emotional intelligence. In patients, loss of prefrontal and orbitofrontal thickness over time was predicted by impaired working memory and emotional intelligence respectively at baseline. Moreover, exploratory analyses revealed that the worsening of negative symptoms over time was significantly related to prefrontal cortical thinning. Results indicate that specific cognitive deficits at the onset of psychotic illness are markers of progressive neuroanatomical deficits and that worsening of negative symptoms occurs with pre-frontal thickness reduction as the illness progresses.
10.1016/j.pscychresns.2020.111100
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