Peer-Reviewed Journal Details
Mandatory Fields
Tardajos, MG,Nash, M,Rochev, Y,Reinecke, H,Elvira, C,Gallardo, A
2012
March
Macromolecular Chemistry And Physics
Homologous Copolymerization Route to Functional and Biocompatible Polyvinylpyrrolidone
Published
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Optional Fields
biocompatibility functionalization monomer reactivity networks polyvinylpyrrolidone RADICAL POLYMERIZATION REACTIVITY RATIOS CARRIER 1-VINYLPYRROLIDIN-2-ONE POLY(VINYLPYRROLIDONE) BIOCONJUGATION CONJUGATE MECHANISM
213
529
538
Linear multifunctional polyvinylpyrrolidone (PVP) chains bearing carboxylate (COO-) or/and sulfonate (SO3-) groups are prepared by standard radical copolymerization of homologous vinylpyrrolidone (VP) and the VP derivatives 3-carboxyvinylpyrrolidone (VPC) and 3-sulfoalkylvinylpyrrolidone (VPS). Functional PVP networks with homogeneous crosslinking density are also prepared using a new homologous water-compatible VP-R-VP crosslinker. This homologous approach for the preparation of functionalized PVP systems is compared theoretically with the preparation of VP with commercial acrylic comonomers bearing similar functionalities. All the linear chains and networks are tested under basic in vitro cell cultures.
DOI 10.1002/macp.201100564
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