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O'Connor, C,O'Shea, PM,Owens, LA,Carmody, L,Avalos, G,Nestor, L,Lydon, K,Dunne, F
Clin Chem Lab Med
Trimester-specific reference intervals for haemoglobin A(1c) (HbA(1c)) in pregnancy
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glycated haemoglobin (HbA(1c)) pregnancy reference intervals trimester WOMEN COMPLICATIONS INSULIN GLUCOSE RISK STANDARDIZATION OUTCOMES TYPE-1 RANGE BLOOD
Background: Diabetes in pregnancy imposes additional risks to both mother and infant. These increased risks are considered to be primarily related to glycaemic control which is monitored by means of glycated haemoglobin (HbA(1c)). The correlation of HbA(1c) with clinical outcomes emphasises the need to measure HbA(1c) accurately, precisely and for correct interpretation, comparison to appropriately defined reference intervals. Since July 2010, the HbA(1c) assay in Irish laboratories is fully metrologically traceable to the IFCC standard. The objective was to establish trimester-specific reference intervals in pregnancy for IFCC standardised HbA(1c) in nondiabetic Caucasian women.Methods: The authors recruited 311 non-diabetic Caucasian pregnant (n=246) and non-pregnant women (n=65). A selective screening based on risk factors for gestational diabetes was employed. All subjects had a random plasma glucose 28 weeks to term.Results: The normal HbA(1c) reference interval for Caucasian non-pregnant women was 29-37 mmol/mol (Diabetes Control and Complications Trial; DCCT: 4.8%-5.5%), T1: 24-36 mmol/mol (DCCT: 4.3%-5.4%), T2: 25-35 mmol/mol (DCCT: 4.4%-5.4%) and T3: 28-39 mmol/mol (DCCT: 4.7%-5.7%). HbA(1c) was significantly decreased in trimesters 1 and 2 compared to non-pregnant women.Conclusions: HbA(1c) trimester-specific reference intervals are required to better inform the management of pregnancies complicated by diabetes.
DOI 10.1515/CCLM.2011.397
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