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McNicholas, BA,Griffin, MD
2012
June
Double-edged sword: a p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury
Published
1
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RENAL ISCHEMIA-REPERFUSION
Acute kidney injury triggers activation of innate immune responses and of proapoptotic programs such as the p53 pathway. Mulay et al. examine the effects of blocking murine double minute-2 (mdm2), a negative regulator of p53, using a novel chemotherapeutic agent, nutlin-3a, in mouse ischemia-reperfusion injury. Their results indicate that mdm2 promotes renal regeneration by limiting p53-mediated apoptosis but also enhances early inflammation by facilitating DNA binding of nuclear factor-kappa B independently of p53.
1161
1164
DOI 10.1038/ki.2012.36
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