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Bree, RT,Stenson-Cox, C,Grealy, M,Byrnes, L,Gorman, AM,Samali, A
2002
February
Cellular longevity: role of apoptosis and replicative senescence
Published
1
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antioxidants apoptosis heat shock proteins oxidative stress telomeres and telomerase HEAT-SHOCK PROTEINS DETECTABLE TELOMERASE ACTIVITY RADICAL-INDUCED APOPTOSIS NORMAL HUMAN-CELLS HUMAN TUMOR-CELLS HUMAN FIBROBLASTS SUPEROXIDE-DISMUTASE CYTOCHROME-C LIFE-SPAN IN-VITRO
Cellular longevity refers to the lifespan of an individual cell. Normal cells have a finite lifespan and typically die by undergoing apoptosis, or enter into a state of irreversible growth arrest, termed replicative senescence, at the end of that lifespan. The lifespan of a cell is a balance between pro-survival/anti-apoptotic and pro-apoptotic death-promoting factors. The role of heat shock proteins, Bcl-2 family members, antioxidant molecules, and telomere length and telomerase activity in the regulation of apoptosis and replicative senescence, will be discussed.
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