Conference Publication Details
Mandatory Fields
Toh, GWL,Lowndes, NF
Role of the Saccharomyces in sensing and responding cerevisiae Rad9 protein to DNA damage
BIOCHEMICAL SOCIETY TRANSACTIONS
2003
February
Published
1
()
Optional Fields
cell cycle protein phosphorylation protein serine/threonine kinase BUDDING YEAST RAD9 CELL-CYCLE REPLICATION CHECKPOINT FHA DOMAIN IN-VIVO S-PHASE PHOSPHORYLATION BRCA1 ATM PATHWAYS
242
246
Eukaryotic cells have evolved surveillance mechanisms, known as DNA-damage checkpoints, that sense and respond to genome damage. DNA-damage checkpoint pathways ensure co-ordinated cellular responses to DNA damage, including cell cycle delays and activation of repair mechanisms. RAD9, from Saccharomyces cerevisiae, was the first damage checkpoint gene to be identified, although its biochemical function remained unknown until recently. This review examines briefly work that provides significant insight into how Rad9 activates the checkpoint signalling kinase Rad53.
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