Other Publication Details
Mandatory Fields
Reviews
O'Croinin, D,Chonghaile, MN,Higgins, B,Laffey, JG
2005
February
Bench-to-bedside review: Permissive hypercapnia
Published
1
Optional Fields
acidosis acute lung injury acute respiratory distress syndrome buffering hypercapnia mechanical ventilation ventilation induced lung injury sepsis RESPIRATORY-DISTRESS-SYNDROME ACUTE LUNG INJURY CYTOPLASMIC PH REGULATION ISCHEMIA-REPERFUSION INJURY ACTIVATED HUMAN-NEUTROPHILS TRADITIONAL TIDAL VOLUMES CARBON-DIOXIDE INTRACELLULAR PH MECHANICAL VENTILATION NITRIC-OXIDE
Current protective lung ventilation strategies commonly involve hypercapnia. This approach has resulted in an increase in the clinical acceptability of elevated carbon dioxide tension, with hypoventilation and hypercapnia 'permitted' in order to avoid the deleterious effects of high lung stretch. Advances in our understanding of the biology of hypercapnia have prompted consideration of the potential for hypercapnia to play an active role in the pathogenesis of inflammation and tissue injury. In fact, hypercapnia may protect against lung and systemic organ injury independently of ventilator strategy. However, there are no clinical data evaluating the direct effects of hypercapnia per se in acute lung injury. This article reviews the current clinical status of permissive hypercapnia, discusses insights gained to date from basic scientific studies of hypercapnia and acidosis, identifies key unresolved concerns regarding hypercapnia, and considers the potential clinical implications for the management of patients with acute lung injury.
51
59
DOI 10.1186/cc2918
Grant Details
Publication Themes