Peer-Reviewed Journal Details
Mandatory Fields
Liew, A,Barry, F,O'Brien, T
2006
March
Bioessays
Endothelial progenitor cells: diagnostic and therapeutic considerations
Published
()
Optional Fields
CORONARY-ARTERY-DISEASE ACUTE MYOCARDIAL-INFARCTION C-REACTIVE PROTEIN BONE-MARROW-CELLS PERIPHERAL-BLOOD IN-VITRO GENE-TRANSFER NEOVASCULARIZATION CAPACITY PULMONARY-HYPERTENSION NEOINTIMA FORMATION
28
261
270
Endothelial progenitor cells (EPCs) may be defined as adherent cells derived from peripheral blood- or bone marrow-derived mononuclear cells demonstrating acLDL uptake and isolectin-binding capacity. The number of circulating EPCs inversely correlates with the number of cardiovascular risk factors and is reduced in cardiovascular disease. This measurement may therefore serves as a surrogate marker for cardiovascular disease risk. EPIC numbers can be modified by various means. However, the effectiveness of risk-factor modification on EPC number and function is currently unknown. Furthermore, EPCs may be used as a potential therapy for a variety of vascular disease states including ischaemia, restenosis and pulmonary hypertension. This review provides an update on multiple factors that affect EPC number as well as highlighting the potential use of EPCs as a novel marker of vascular dysfunction. Furthermore, potential gene- and/or EPC-based approaches to a number of vascular disease states are explored.
DOI 10.1002/bies.20372
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