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Rea, K,Roche, M,Finn, DP
2007
November
Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate
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1
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pain brain cannabinoids GABA glutamate neurotransmission nociception ACID AMIDE HYDROLASE HIPPOCAMPAL ACETYLCHOLINE-RELEASE ROSTRAL VENTROMEDIAL MEDULLA RECEPTOR-MEDIATED INHIBITION VENTRAL TEGMENTAL AREA STRESS-INDUCED ANALGESIA CENTRAL-NERVOUS-SYSTEM MESOLIMBIC DOPAMINE TRANSMISSION VANILLOID TYPE-1 RECEPTORS NUCLEUS-ACCUMBENS SHELL
Recent physiological, pharmacological and anatomical studies provide evidence that one of the main roles of the endocannabinoid system in the brain is the regulation of gamma-aminobutyric acid (GABA) and glutamate release. This article aims to review this evidence in the context of its implications for pain. We first provide a brief overview of supraspinal regulation of nociception, followed by a review of the evidence that the brain's endocannabinoid system modulates nociception. We look in detail at regulation of supraspinal GABAergic and glutamatergic neurons by the endocannabinoid system and by exogenously administered cannabinoids. Finally, we review the evidence that cannabinoid-mediated modulation of pain involves modulation of GABAergic and glutamatergic neurotransmission in key brain regions.
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DOI 10.1038/sj.bjp.0707440
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