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McCabe, C,Samali, A,O'Brien, T
2006
May
Cytoprotection of beta cells: rational gene transfer strategies
Published
1
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islet allografts beta cells gene transfer vectors cytoprotection antioxidants anti-apoptotic cytokines oxidative stress DEPENDENT DIABETES-MELLITUS NITRIC-OXIDE PRODUCTION PANCREATIC-ISLET CELLS FACTOR-KAPPA-B ADENOASSOCIATED VIRUS VECTORS ENDOPLASMIC-RETICULUM STRESS CYTOKINE-INDUCED DESTRUCTION INSULIN-PRODUCING CELLS OXYGEN-FREE RADICALS INDUCED APOPTOSIS
Gene transfer to pancreatic islets may prove useful in preventing islet cell destruction and prolonging islet graft survival after transplantation in patients with type 1 diabetes mellitus (T1DM). Potentially, a host of therapeutically relevant transgenes may be incorporated into an appropriate gene delivery vehicle and used for islet modification. An increasing understanding of the molecular pathogenesis of immune-mediated beta cell death has served to highlight molecules which have become suitable candidates for promoting islet cell survival in the face of oxidative stress. This review aims to give an overview of some conventional gene transfer strategies aimed at promoting islet cell survival in the face of cytokine onslaught. These strategies target three aspects of islet cell physiology: redox status and antioxidant defence, anti-apoptotic gene expression and mediators of cytokine signal transduction pathways. Copyright (c) 2006 John Wiley & Sons, Ltd.
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DOI 10.1002/dmrr.615
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