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Read, DE,Gorman, AM
2009
April
Heat shock protein 27 in neuronal survival and neurite outgrowth
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1
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Akt Cell death Neurodegeneration Neuroregeneration ALPHA-B-CRYSTALLIN MARIE-TOOTH-DISEASE INDUCED CELL-DEATH NERVE INJURY PC12 CELLS NEURODEGENERATIVE DISEASES MOTOR-NEURONS UP-REGULATION IN-VITRO HSP27
The small heat shock protein 27 (Hsp27) is well documented to promote neuronal survival in neurodegenerative diseases and following nerve injury. It can directly inhibit apoptotic pathways, and as a chaperone it can ameliorate the toxic effects of misfolded proteins. More recently, Hsp27 has been implicated to also play a role in neurite outgrowth. Thus, Hsp27 is situated at the intersection of neuronal survival and differentiation and, as such, it has dual potential as a key therapeutic target for neuroregeneration. (C) 2009 Elsevier Inc. All rights reserved.
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DOI 10.1016/j.bbrc.2009.02.114
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